I-mfa and TRPC1 Channel Regulation of Glomerular Filtration Rate in Mouse Models

Experimental data from Harvard Dataverse, last updated May 2026, by author Ma, Rong. The dataset contains measurements of glomerular filtration rate (GFR) and cell contractility in I-mfa knockout and wild-type mice, alongside protein abundance and calcium entry responses in mesangial cells.

Use Cases

• Compare glomerular filtration rates based on I-mfa knockout status in mice.
• Analyze contractile function in human and mouse mesangial cells based on I-mfa overexpression or knockdown.
• Investigate TRPC1 and TRPC6 protein abundance based on I-mfa deletion in primary cells.
• Model calcium entry responses in human mesangial cells based on I-mfa knockdown.

Strengths

• Includes comparative data from both knockout and wild-type mouse models.
• Covers multiple experimental layers: in vivo GFR, in vitro cell contractility, protein abundance, and calcium signaling.
• Data is hosted on the authoritative Harvard Dataverse platform.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale analysis.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Harvard Dataverse

Collection Method

Likely contains experimental measurements from biological assays.

Time Range

The dataset's temporal coverage is not specified in the input.

Freshness

Last updated 2026-05-01 13:17:18; freshness should be verified.

Geography

The dataset's geographic coverage is not specified in the input.