Supporting Data for Roles of PIPs in DNA Damage-Inflicted Nuclear Body Assembly

Nan Xiong published supporting data for a study on the roles of phosphatidylinositol phosphates in DNA damage-inflicted nuclear body assembly. The data was uploaded to figshare on June 1, 2026, under a CC-BY-NC-4.0 license. The research explores how PI(3)P binding to the 53BP1 BRCT domain drives phase separation for early DNA repair responses.

Use Cases

• Validate the role of PI(3)P in stimulating 53BP1 condensation based on in vitro assay data.
• Analyze the relationship between IPMK activity and early 53BP1 foci assembly based on depletion/mutant experiments.
• Compare properties of early versus late 53BP1 nuclear bodies based on sensitivity to LLPS inhibitors like 1,6-hexanediol.
• Investigate the cell cycle dependency of early 53BP1 foci formation based on enrichment in G1 phase data.

Strengths

• Data supports a specific, peer-reviewed research finding on a novel lipid-signaling axis in DNA repair.
• The dataset is associated with a study that includes multiple experimental approaches (in vitro, in vivo, mutational analysis).
• Last updated date is explicitly provided as 2026-06-01 01:49:34.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The description is detailed on the biological context but does not specify the data's structure or file formats.

Provenance

Source

figshare, author Nan Xiong

Collection Method

Likely contains experimental data generated to support the described research findings.

Freshness

Last updated 2026-06-01 01:49:34; freshness should be verified.