Icariin Effects on Triple-Negary Breast Cancer via SIRT6/NF-κB Signaling

A research dataset from Chengdu University of Traditional Chinese Medicine investigates the natural compound icariin. It contains results from cytotoxicity, proliferation, apoptosis, migration, and invasion assays on TNBC cells and a tumor mouse model. The data includes western-blot and transcriptomic analysis of the SIRT6/NF-κB/EMT signaling pathway and tumor immunosuppressive microenvironment regulation.

Use Cases

• Train models to predict drug cytotoxicity based on concentration- and time-dependent response data.
• Analyze gene expression patterns linked to NF-κB/EMT pathway inhibition from transcriptomic data.
• Study correlations between SIRT6 upregulation and anti-metastatic effects in cancer cell assays.
• Investigate the relationship between mitochondrial apoptosis markers (Bax/Bcl-2 ratio, ROS) and drug-induced cell death.

Strengths

• Data includes results from both in vitro cell assays and an in vivo tumor mouse model.
• Analysis covers multiple experimental endpoints: cytotoxicity, proliferation, apoptosis, migration, and invasion.
• Mechanistic insights are supported by western-blot and transcriptomic analysis of a specific signaling pathway.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect the specific experimental bias inherent to paperswithcode platform listings.

Provenance

Source

Linjiang Song, Chengdu University of Traditional Chinese Medicine

Collection Method

Experimental data from cytotoxicity, anti-proliferation, apoptotic induction, anti-migration, anti-invasion assays, western-blot, and transcriptomic analysis.