Adverse Drug Reactions to Antipsychotics in a Tertiary Care Hospital, 517 Patients

A prospective interventional study from an Indian tertiary care hospital identified 289 adverse drug reactions (ADRs) among 517 patients receiving antipsychotics, representing an incidence rate of 41.97%. The research, authored by Dushad Ram, monitored patients of any age and either sex prescribed at least one antipsychotic. Sixty-seven different kinds of ADRs were observed, with the central and peripheral nervous system being the most commonly affected organ class.

Use Cases

• Analyzing the incidence and spectrum of adverse drug reactions based on the reported 67 different ADR types
• Comparing the safety profiles of specific antipsychotics like olanzapine and risperidone based on their reported ADR counts
• Studying intervention strategies for ADR management based on the reported 80% of cases requiring action
• Investigating organ system susceptibility to antipsychotic side effects based on the reported most commonly affected system organ class

Strengths

• Study includes 517 patient records, providing a substantive sample size
• Identifies 289 specific adverse drug reactions, allowing for detailed analysis
• Reports an overall ADR incidence rate of 41.97%, a key quantitative finding
• Lists the most commonly implicated drugs (olanzapine, n=92; risperidone, n=59) and the most common ADR (weight gain, n=30)

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download
• Data may reflect geographic and institutional bias inherent to a single tertiary care hospital in India
• Last update date is unknown; freshness unverified

Provenance

Source

Dushad Ram

Collection Method

Prospective interventional study conducted in the psychiatric unit of a tertiary care hospital

Geography

India (inferred from description context)