CSH-4044: A Benzothiazole Inhibitor of PIM and DYRK Kinases

A 99.0 B dataset from figshare, authored by Gyula Bencze and last updated in March 2026. It contains data related to the identification and validation of a novel small-molecule protein kinase inhibitor, designated F10V6W0/CSH-4044, isolated from fermented wheat germ extract. The dataset likely includes results from kinase profiling, structural elucidation, and functional assays in pancreatic cancer and neuronal cell models.

Use Cases

• Validate kinase inhibitor selectivity based on kinase profiling data mentioned in the description.
• Analyze structure-activity relationships based on the cocrystal structure of CSH-4044 bound to PIM1.
• Model compound effects on cellular pathways based on suppression of PIM3-driven BAD phosphorylation.
• Investigate therapeutic potential for neurodegenerative conditions based on reduction of DYRK1A-mediated Tau phosphorylation.

Strengths

• Dataset is associated with a specific, characterized compound (CSH-4044/F10V6W0).
• Research includes multiple validation methods, such as X-ray crystallography and kinase profiling.
• License (CC-BY-NC-4.0) is clearly specified.

Limitations

• Dataset size is only 99.0 B, indicating very limited scope or a metadata-only file.
• Row count and column definitions are unknown, limiting suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare, author Gyula Bencze.

Collection Method

Data likely generated from preparative HPLC, X-ray crystallography, and in vitro cell assays described in the study.

Freshness

Last updated 2026-03-18 21:13:54; freshness should be verified.