CSH-4044: PIM and DYRK Kinase Inhibitor Characterization Data

Gyula Bencze published a dataset on figshare in March 2026 detailing the identification and validation of a novel benzothiazole kinase inhibitor. The data, stored in a 2.8 KB CSV file, includes results from kinase profiling, X-ray crystallography, and functional assays in pancreatic cancer and neuronal cell models. The work characterizes the compound F10V6W0 and its synthetic analog CSH-4044, which selectively targets PIM and DYRK protein kinase families.

Use Cases

• Validate kinase inhibitor selectivity based on the reported kinase profiling data.
• Analyze protein-ligand interactions based on the cocrystal structure of CSH-4044 bound to PIM1.
• Model structure-activity relationships for benzothiazole compounds based on the described chemical synthesis.
• Investigate the therapeutic potential of fermented wheat germ extract constituents based on the isolation and characterization workflow.

Strengths

• Dataset includes structural data from X-ray crystallography, as mentioned in the description.
• The compound's biological activity was validated in two distinct cell models (pancreatic cancer and neuronal cells).
• Data is associated with a specific, synthesized compound (CSH-4044) with confirmed structural integrity.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Gyula Bencze via figshare

Collection Method

Data generated through preparative high-performance liquid chromatography, X-ray crystallography, kinase profiling, and cell-based functional assays.

Freshness

Last updated 2026-03-18 21:13:56; freshness should be verified.