N24: Small-Molecule Inhibitor Data for Rapid-Acting Antidepressant Research

Figshare data from Liting Zhang, last updated in June 2026, details the identification of a small-molecule inhibitor called N24. The dataset includes experimental results such as a thermal shift of 5.44 °C and an IC50 of 0.76 ± 0.07 μM, supporting its potential as a rapid-acting antidepressant. The data is provided in a 1.9 KB CSV file.

Use Cases

• Training predictive models for small-molecule binding affinity based on reported IC50 and thermal shift values.
• Benchmarking computational docking simulations against the provided cocrystal structure interactions.
• Analyzing dose-response relationships for antidepressant efficacy using the in vivo mouse model results.

Strengths

• Includes specific, quantitative experimental results like a ΔTm of 5.44 °C and an IC50 of 0.76 ± 0.07 μM.
• Data is associated with a peer-reviewed research finding, including in vivo validation in two mouse models.
• File size of 1.9 KB indicates a focused, likely well-structured dataset for its specific purpose.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The 1.9 KB size suggests a very limited scope, likely containing summary results rather than raw experimental data.

Provenance

Source

figshare

Collection Method

Experimental research data from biochemical assays (DSF, FP) and in vivo mouse models.

Freshness

Last updated 2026-06-03 20:13:58; freshness should be verified.