Imidazo[4,5-c]pyridine-6-Carboxamide Antimalarial Efficacy and Resistance Data

Bo Zhou's dataset on figshare, last updated April 28, 2026, describes a novel antimalarial chemotype. The data likely contains results from in vivo mouse studies and in vitro resistance screens for compound 10b, an orally efficacious imidazo[4,5-c]pyridine-6-carboxamide. The dataset is 4.4 KB in size and is shared under a CC-BY-NC-4.0 license.

Use Cases

• Analyzing in vivo efficacy based on oral dosing regimens and cure rates in Plasmodium yoelii-infected mice.
• Evaluating resistance profiles based on results from the AReBaR resistome screen with over 40 distinct mutations.
• Assessing compound activity against dormant parasites based on 6-hour exposure kill rates for proliferating and artemisinin-induced rings.
• Comparing the resistance selection barrier based on the minimum inoculum of resistance (10^9 parasites) test.

Strengths

• Data is associated with a compound demonstrating a high barrier to resistance, being refractory to selection at 10^9 parasites.
• Compound 10b was unaffected by over 40 distinct target- and efflux-based resistance mutations in screening.
• The dataset includes results for a compound active against both proliferating rings and dihydroartemisinin-induced dormant parasites.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (4.4 KB), indicating limited scope.

Provenance

Source

Bo Zhou via figshare

Collection Method

Likely experimental results from pharmacological and parasitological studies.

Time Range

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Freshness

Last updated 2026-04-28 03:09:47; freshness should be verified.

Geography

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