Mitochondrial Gene Expression in Radiation-Induced Intestinal Injury

Mrm2 was identified as a key regulatory factor in mitochondrial dysfunction during radiation-induced intestinal injury (RIII). The study by Zhongwei Zhang, published on figshare in April 2026, includes data from a series of mitochondrial-related differentially expressed genes identified in an RIII model. Core functional modules include mitochondrial-coding genes and apoptosis-related genes.

Use Cases

• Analyze the dose-dependent and time-dependent aggravation of RIII using histopathological staining data.
• Investigate the correlation between Mrm2 upregulation and mitochondrial dysfunction features post-irradiation.
• Validate identified mitochondrial-related differentially expressed genes as potential biomarkers for RIII risk stratification.
• Study the functional modules containing mitochondrial-coding genes and apoptosis-related genes in the RIII model.

Strengths

• Data is associated with a specific, peer-reviewed research finding on Mrm2's role in RIII.
• Dataset is openly available under a CC-BY-4.0 license for reuse and modification.

Limitations

• The dataset is relatively small at 7.2 MB, limiting the scope for large-scale machine learning analysis.
• Specific row counts, column names, and sample data are unavailable, hindering immediate usability assessment.
• Data originates from a specific experimental model, which may limit direct generalizability to human patients.

Provenance

Source

figshare, authored by Zhongwei Zhang.

Collection Method

Generated from bioinformatics analysis of an RIII (radiation-induced intestinal injury) model.

Freshness

Last updated on 2026-04-03.