Identification of Nitric Oxide-Donating Lenumlostat Derivatives with Dual Activities of Ex

A dataset from a pharmacology study on novel compounds for treating pulmonary arterial hypertension (PAH). The research designed and synthesized nitric oxide-donating lenumlostat derivatives and evaluated their biological activity in vitro and in rat models. The dataset, authored by Yuanbo Hu and last updated in April 2026, is hosted on figshare under a CC-BY-NC-4.0 license.

Use Cases

• Training predictive models for drug efficacy based on LOXL2 inhibitory activity and vasodilation data.
• Analyzing structure-activity relationships for nitric oxide-donating derivatives.
• Benchmarking new compounds against lenumlostat using metrics like right ventricular systolic pressure reduction.
• Studying the correlation between collagen cross-linking suppression and improvements in pulmonary arterial medial wall thickness.

Strengths

• Data is derived from a study with explicit in vitro and in vivo biological evaluations.
• Results include comparative efficacy data against the parent compound lenumlostat.
• The dataset is associated with a specific, peer-reviewed research objective detailed in the description.

Limitations

• The dataset is extremely small at 859.0 B, indicating very limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Experimental data from the synthesis and biological evaluation of novel compounds.

Time Range

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Freshness

Last updated 2026-04-22 16:09:53; freshness should be verified.

Geography

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