Identification of Non-competitive and Reversible Inhibitors of Glycine Transporter 2: A Pr

5.4 KB of data from a study by Christopher L. Cioffi, published on figshare in April 2026. The dataset likely contains results from screening a series of conformationally restricted indoline analogues as noncompetitive and reversible inhibitors of Glycine Transporter 2 (GlyT2). This work provides a foundation for optimizing safe, nonopioid therapeutics for neuropathic pain management.

Use Cases

• Compare inhibitor potency and recovery kinetics based on the described series of indoline analogues.
• Identify candidate compounds for preclinical selection based on the described efficacy in murine models.
• Analyze structure-activity relationships for noncompetitive GlyT2 inhibitors based on the described chemotype.
• Investigate the translational potential of reversible inhibitors for neuropathic pain based on the described findings.

Strengths

• Data is associated with a specific, peer-reviewed research study on a promising therapeutic target.
• File is small (5.4 KB), facilitating quick download and initial inspection.
• Dataset has a clear, non-commercial license (CC-BY-NC-4.0).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Christopher L. Cioffi via figshare.

Collection Method

Likely generated from laboratory experiments screening inhibitor compounds.

Time Range

The study and associated data were made available in 2026.

Freshness

Last updated 2026-04-16 03:29:28; freshness should be verified.

Geography

Geographic coverage of the research is not specified.