Kawasaki Disease Transcriptomic Data with Tryptophan Metabolism Biomarkers

Transcriptomic data from the Gene Expression Omnibus includes a training set of 76 Kawasaki Disease patients and 37 healthy controls from GSE68004, plus a validation set of 78 patients and 55 controls from GSE73461. The dataset is curated for analyzing 40 Tryptophan Metabolism-Related Genes (TMRGs) as potential biomarkers.

Use Cases

• Identify Kawasaki Disease biomarkers by analyzing expression patterns of the 40 Tryptophan Metabolism-Related Genes (TMRGs) across patient and control samples.
• Validate gene signatures from the GSE68004 training cohort using the independent GSE73461 validation cohort of patient and control samples.
• Perform differential expression analysis on peripheral blood transcriptomic data to compare Kawasaki Disease patients against healthy controls.

Strengths

• Includes two independent cohorts for training and validation, with a combined total of 154 Kawasaki Disease patients and 92 healthy controls.
• Focuses on a curated set of 40 Tryptophan Metabolism-Related Genes (TMRGs) for targeted biomarker analysis.
• Data sourced from the authoritative Gene Expression Omnibus (GEO) repository under consistent platform GPL10558.

Limitations

• Sample sizes per cohort are moderate (76-78 patients), which may limit statistical power for detecting subtle gene expression differences.
• Limited to peripheral blood samples, potentially missing tissue-specific gene expression relevant to Kawasaki Disease pathology.

Provenance

Source

Gene Expression Omnibus (GEO) datasets GSE68004 and GSE73461.

Collection Method

Transcriptomic data from peripheral blood samples of Kawasaki Disease patients and healthy controls, curated with 40 TMRGs from the Molecular Signatures Database.

Time Range

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Freshness

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Geography

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