Human Gene Expression Response to Radiation Doses at 1 Hour Post-Exposure

Sixteen human blood samples were irradiated at four dose levels to identify genetic biomarkers for radiation exposure. The dataset contains gene expression measurements from four volunteers, with four replicates per dose level, taken 1 hour post-exposure. NASA produced this data to support early diagnosis tools for astronauts facing ionizing radiation risks on long-duration space missions.

Use Cases

• Identify dose-dependent genetic biomarkers for radiation exposure based on transcriptional analysis.
• Train classifiers to predict radiation dosage levels based on gene expression patterns.
• Validate lab-on-a-chip (LOC) sensor targets using the identified upregulated biomarkers.
• Study immediate human transcriptional response to high-energy particle radiation.

Strengths

• Data includes four biological replicates per radiation dose level (0, 0.3, 1.5, 3.0 Gy).
• Samples were collected at a consistent 1-hour post-exposure time point.
• Gene expression was measured using a standardized Affymetrix GeneChip platform.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset's small sample size (16 total samples) may limit statistical power.

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Blood samples from four human volunteers were irradiated, leukocytes extracted, and gene expression measured using Affymetrix GeneChip Human Gene 1.0 ST v1 Array chips.

Time Range

Measurements taken at 1 hour post-exposure.

Freshness

Last updated 2026-03-13 19:19:43.301280; freshness should be verified

Geography

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