Impact of <i>Enterobius vermicularis</i> infection and mebendazole treatment o

109 first and fourth grade primary school children in Taichung, Taiwan, were recruited for a gut microbiome and immune response study. The research, conducted by Chin-An Yang of China Medical University, examined changes in microbial diversity and cytokine levels before and after pinworm infection and mebendazole treatment. Gut microbiota diversity increased after Enterobius infection and peaked after administration of mebendazole.

Use Cases

• Modeling changes in gut microbial diversity based on pinworm infection status and treatment.
• Analyzing shifts in specific bacterial phyla like Actinobacteria and Fusobacteria in response to parasitic infection.
• Investigating the relationship between pre-treatment Salmonella spp. abundance and post-treatment SIgA immune response.
• Studying the correlation between intestinal SIgA levels and Enterobius vermicularis infection in a pediatric cohort.

Strengths

• Data is derived from a study of 109 pediatric participants, providing a specific cohort size.
• Includes paired pre- and post-treatment samples for the infected group, collected 2 weeks after mebendazole administration.
• Analysis covers multiple biological levels: gut microbiome composition at phylum and genus level, and host immune markers (cytokines, SIgA).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Last update date is unknown; freshness unverified.

Provenance

Source

Chin‐An Yang, China Medical University

Collection Method

Clinical study recruiting 109 primary school children for fecal sample collection and analysis.

Geography

Taichung, Taiwan