Commercial Plasma Proteome Recovery Data from Five Sources

Figshare hosts a dataset investigating variability in plasma proteome recovery from five commercial sources. The study compares a particle-based protein enrichment strategy against a conventional workflow, analyzing samples with two mass spectrometry instruments and search algorithms. Data is provided in an XLSX file sized 2.6 MB.

Use Cases

• Compare protein enrichment yields, ranging from 2.8- to 6.2-fold, across different commercial plasma sources.
• Analyze proteome composition variability attributable to differences in whole blood-to-plasma operating procedures.
• Benchmark proteome profiling results from two distinct instruments, Exploris 480 and timsTOF HT.
• Evaluate the performance of different search algorithms, CHIMERYS and DIA-NN, on the acquired plasma proteomics data.

Strengths

• Data derived from plasma samples sourced from five distinct commercial providers.
• Analysis performed using two distinct mass spectrometry instruments and two search algorithms.
• Particle-based enrichment achieved yields exceeding 5000 proteins on the timsTOF HT instrument.

Limitations

• The dataset is small at 2.6 MB, limiting the scale of potential analysis.
• Specific row and column counts are unknown, making data structure and volume unclear.
• Focus is on methodological comparison; may not be directly generalizable to diseased-state plasma studies.

Provenance

Source

Figshare, author Taku Kasai.

Collection Method

Mass spectrometry analysis of commercial plasma samples using data-independent acquisition mode.

Time Range

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Freshness

Last updated March 2026.

Geography

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