Mouse Liver Oxidative Stress Data from Vitamin C and Cyclophosphamide Study

Thirty-two 45-day-old female Swiss mice were used to study vitamin C's effects on oxidative damage from cyclophosphamide. Biochemical analyses measured lipid peroxidation and reduced glutathione levels in liver tissue after a six-day treatment period. The dataset originates from an open-access research paper by Évelyn de Sousa ARAÚJO.

Use Cases

• Analyzing the relationship between cyclophosphamide dosage and lipid peroxidation levels based on the described experimental results.
• Modeling the interaction effect of vitamin C and cyclophosphamide on reduced glutathione levels based on the study's findings.
• Comparing oxidative stress biomarker responses across control and treatment groups as detailed in the methodology.

Strengths

• Experimental design includes four distinct treatment groups with eight animals each, allowing for controlled comparisons.
• Specific biochemical endpoints are measured: lipid peroxidation via thiobarbituric acid-reactive substances and reduced glutathione via non-protein thiols.
• Precise dosages are provided: vitamin C at 50 mg/kg and cyclophosphamide at 100 + 150 mg/kg.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• Last update date is unknown; freshness unverified.
• Data scale is limited to a single study with 32 animals, which may limit generalizability.

Provenance

Source

paperswithcode

Collection Method

Laboratory experiment involving intraperitoneal administration of substances and subsequent biochemical analysis of mouse liver tissue.