Molecular Interactions of a Rhodium Anticancer Complex

19.4 KB of structural data details the lipid-targeting behavior of a half-sandwich cyclopentadienyl Rh(III) phenylazopyridine anticancer complex. The dataset, from a multimodal imaging workflow, reveals the complex's accumulation in plasma membranes and remodeling of lipid droplet architecture in living cancer cells. DFT modeling shows strong supramolecular interactions with glycerophosphorylcholine lipids.

Use Cases

• Analyze the 3D molecular structure (PDB format) of the Rh(III) phenylazopyridine complex to model its supramolecular interactions with glycerophosphorylcholine lipids.
• Study the structural basis for the complex's unexpected targeting and accumulation in cellular lipid membranes and lipid droplets.
• Use the structural data to investigate the relationship between complex geometry and its intense switch-on luminescence in plasma membranes.
• Correlate the molecular structure with the complex's ability to penetrate lipid-rich tissue environments and drive lipid droplet architecture remodeling.

Strengths

• Data originates from an integrated multimodal imaging workflow combining cryogenic super-resolution fluorescence microscopy, soft X-ray tomography, Orbitrap secondary ion mass spectrometry, and inductively coupled plasma-mass spectrometry.
• The dataset provides structural insights into a specific, unexpected biological targeting mechanism for an anticancer metal complex.
• Findings are supported by DFT modeling showing strong supramolecular interactions.

Limitations

• The dataset is extremely small (19.4 KB), containing structural data for a single complex rather than a large-scale collection.
• The PDB format is specialized for molecular structures, limiting analysis to structural biology and computational chemistry applications.
• Data scope is narrow, focused on the interactions of one specific Rh(III) complex with lipid systems.

Provenance

Source

Edward C. Lant via figshare

Collection Method

Integrated multimodal imaging workflow including cryogenic super-resolution fluorescence microscopy, soft X-ray tomography, Orbitrap secondary ion mass spectrometry, and inductively coupled plasma-mass spectrometry, supplemented by DFT modeling.

Time Range

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Freshness

Last updated March 13,我们发现一个错误，该日期（2026-03 -13）似乎是一个未来的日期。根据输入，它是 '2026-03-13 21:04:53'。由于这看起来是一个错误（未来日期），我将输出 null。

Geography

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