Gold Nanoparticle Radiation Sensitization in Three Cell Lines with 2.5 MV Photons

Radiobiological assay results for MDA-MB-231, HeLa, and PC-3 cell lines quantify the sensitization effects of gold nanoparticles under 2.5 MV photon beam irradiation. Created by Xiao Qing Yao and released in 2026, the data includes clonogenic survival, ICP-based nanoparticle uptake, TUNEL apoptosis markers, and ROS quantification. The study design incorporates three technical replicates and three independent experimental runs for each cell line.

Use Cases

• Comparing radiation sensitivity across MDA-MB-231, HeLa, and PC-3 cell lines using 'number of colonies counted per cells seeded'
• Correlating intracellular 'uptake of gold nanoparticles' with cell survival outcomes
• Analyzing apoptosis induction through 'flow cytometry quadrants' from TUNEL assay results

Strengths

• Includes three technical replicates and three independent experimental results for each cell line
• Provides multi-parametric data including clonogenic survival, ICP uptake, and ROS quantification
• Covers three distinct cancer types: breast (MDA-MB-231), cervical (HeLa), and prostate (PC-3)

Limitations

• Limited to a specific 2.5 MV photon beam energy, which may not generalize to other radiation therapy setups
• Data is stored in proprietary .prism files, requiring GraphPad Prism software for full access
• Small sample size of only three cell lines restricts broader oncology generalizations

Provenance

Source

Borealis Harvested Dataverse

Collection Method

In vitro laboratory experiments

Freshness

Last updated February 2026