Severe Pertussis Risk Factors in Chinese Children: Meta-Analysis

Yingying Yang's meta-analysis aggregates data from 24 studies covering 839 severe pertussis cases and 4,280 non-severe cases in Chinese children. It quantifies the association strength of clinical and demographic factors with severe disease outcomes. The analysis includes odds ratios and weighted mean differences for factors like lung consolidation and vaccination status.

Use Cases

• Model the risk of severe pertussis using odds ratios for factors like lung consolidation or atelectasis and unvaccinated with DTP vaccine status.
• Analyze the association strength between elevated C-reactive protein levels and white blood cell count with severe clinical outcomes.
• Validate clinical triage protocols by examining the predictive power of the three concave sign and other identified risk factors.

Strengths

• Analysis synthesizes evidence from 24 distinct studies.
• Includes data on 5,119 total cases (839 severe, 4,280 non-severe).
• Reports specific, quantified associations (e.g., OR: 15.44 for lung consolidation).

Limitations

• Small dataset scope (658.4 KB) containing summary statistics, not individual patient records.
• Findings are specific to the Chinese pediatric population and may not generalize globally.
• Relies on published study data up to September 2025, which may not include the most recent clinical trends.

Provenance

Source

Yingying Yang via figshare.

Collection Method

Systematic literature review and meta-analysis of studies from PubMed, Embase, Web of Science, CNKI, and Wanfang.

Time Range

Literature reviewed up to September 30, 2025.

Freshness

Last updated March 2026, based on literature up to September 2025.

Geography

China (Chinese children).