Integrated clinical and computational data-based repurposing of econazole as a novel autop

Jin Zhang published a research document on figshare in 2026 detailing a drug repurposing study for Parkinson disease. The 1.7 MB document integrates clinical data analysis and computational screening to identify econazole as a novel autophagy activator. It describes therapeutic effects in multiple PD models, including MPTP-induced zebrafish and mouse models.

Use Cases

• Validate autophagy activation pathways based on described ULK1-HSPA8 interaction and phosphoproteomic profiling.
• Assess neuroprotective drug candidates based on screening results from MPTP-induced and SNCA mutant models.
• Study ULK1-dependent autophagy mechanisms in Parkinson disease based on clinical data associations and mechanistic findings.

Strengths

• The study integrates clinical data analysis with results from multiple model organisms, including zebrafish and mice.
• The document is published under a permissive CC-BY-4.0 license, allowing for broad reuse.

Limitations

• The dataset consists of a single 1.7 MB DOCX file, limiting direct computational analysis of structured data.
• Column-level documentation is absent; field semantics must be inferred from the text after download.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

figshare

Collection Method

Integrated clinical data analysis and systematic computational screening.

Freshness

Last updated 2026-05-11 12:30:49; freshness should be verified.