Integrated Transcriptomic and Metabolomic Analyses of DARS in Human MPN Cell Models

Multi-omics data from a study investigating the pro-proliferative role of the DARS gene in human myeloproliferative neoplasm cell models. The dataset includes metabolomic analysis identifying 190 differential metabolites and transcriptomic analysis showing altered expression of more than 2,000 genes. It was authored by Hao Xiong and last updated on 2026-05-24.

Use Cases

• Identify cancer-related metabolic pathways based on the 190 differential metabolites mentioned in the description
• Analyze gene expression changes associated with DARS depletion based on the more than 2,000 altered genes
• Investigate integrated molecular mechanisms based on the combined transcriptomic and metabolomic data
• Validate findings in independent MPN datasets based on the public dataset re-analysis mentioned

Strengths

• Integrated multi-omics data combining transcriptomic and metabolomic analyses
• Metabolomic analysis identified 190 differential metabolites
• Transcriptomic analysis associated DARS depletion with altered expression of more than 2,000 genes
• Data is openly available under a CC-BY-4.0 license

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Data is small in scale at 1.6 MB

Provenance

Source

figshare

Collection Method

Experimental data from human MPN cell model studies using integrated multi-omics approaches.

Freshness

Last updated 2026-05-24 17:40:05; freshness should be verified