Integrated transcriptomic and proteomic analysis reveals inflammatory activation and blood

A figshare-hosted dataset by Zhiwei Li, last updated in May 2026, containing 4.5 MB of supplementary files for a study on meningitis. It includes transcriptomic and proteomic data from a mouse model infected with Escherichia coli strain RS218, comparing results to mock conditions. The data comprises differential expression analyses, principal component analyses, and blood parameter measurements at 4 and 12 hours post-infection.

Use Cases

• Identify differentially expressed genes and proteins based on transcriptomic and proteomic volcano plots.
• Perform pathway enrichment analysis based on the top 100 enriched terms listed for upregulated and downregulated genes/proteins.
• Investigate correlations between gene and protein expression levels based on tables of co-upregulated and co-downregulated abundance.
• Analyze temporal changes in blood biochemical and hematological parameters based on measurements taken at 4 and 12 hours post-infection.

Strengths

• Dataset integrates both transcriptomic and proteomic data from the same experimental setup.
• Includes time-series blood parameter data from two post-infection time points (4 and 12 hours).
• License is CC-BY-4.0, allowing for broad reuse and sharing.

Limitations

• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The 4.5 MB size suggests a relatively small dataset, potentially limiting the scope of secondary analyses.
• Description metadata is limited; actual data quality and structure require inspection of the XLSX and TIF files.

Provenance

Source

figshare

Collection Method

Likely generated from laboratory experiments on a mouse model infected with E. coli strain RS218.

Freshness

Last updated 2026-05-02 22:56:56; freshness should be verified.