F-53B Developmental Neurotoxicity Risk Assessment Data

19.9 KB of Excel data supports a quantitative risk assessment of the developmental neurotoxicity of F-53B, a PFOS replacement. The study by Longfei Feng integrates in vitro phenotypic profiling, transcriptomics, adverse outcome pathway modeling, and pharmacokinetic modeling. It estimates fetal brain concentrations of 0.09–14.66 ng/mL based on human biomonitoring data.

Use Cases

• Quantifying benchmark doses for chemical toxicity based on in vitro phenotypic data.
• Estimating human-relevant fetal exposure levels using physiologically based pharmacokinetic modeling.
• Analyzing the probability of adverse outcomes across exposure gradients via adverse outcome pathway–Bayesian network models.
• Investigating the relationship between oxidative stress, mitochondrial dysfunction, and compromised neurogenesis.

Strengths

• Data underpins a quantitative testing strategy integrating multiple modeling approaches.
• Provides a specific benchmark dose of 3.26 μmol/g of protein for learning and memory impairment.
• Estimates fetal brain concentration ranges (0.09–14.66 ng/mL) based on human biomonitoring.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (19.9 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Derived from in vitro experiments with human embryonic neural stem cells, transcriptomics, and computational modeling.

Freshness

Last updated 2026-05-05 04:13:42; freshness should be verified.