DNA Damage in Endothelial Cells from Monoenergetic Neutron Exposure

Experimental and simulation data from three independent experiments irradiating primary endothelial cells with monoenergetic neutrons at 2.5 or 15.1 MeV. DNA damage was assessed via γ-H2AX foci formation 30 minutes post-irradiation, with doses under 0.12 Gy. The dataset was authored by Géraldine Gonon and last updated on 2026-05-20.

Use Cases

• Model DNA damage yields based on neutron energy and depth parameters
• Analyze linear foci patterns linked to secondary particle tracks
• Compare experimental γ-H2AX foci counts with Monte Carlo simulation outputs
• Study energy-dependent biological impact in line with ICRP weighting factors

Strengths

• Includes data from three independent experimental replicates per setup
• Combines experimental results with Monte Carlo simulations (Geant4)
• Provides specific DSB induction rates (e.g., 37.5–38.6 DSBs per nucleus per Gy at 2.5 MeV)
• Reports foci yields ranging from 14.3 to 21.7 foci per nucleus per Gy

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Dataset size is 7.0 MB, indicating a relatively small scale

Provenance

Source

figshare

Collection Method

Cells were irradiated on a human torso water phantom, and DNA damage was assessed by γ-H2AX foci formation.

Freshness

Last updated 2026-05-20 23:00:57