Integration of single-cell transcriptome and chromatin accessibility of early gonads devel

Integrated single-cell transcriptome and chromatin accessibility data from early gonads of goats, pigs, macaques, and humans. The dataset, from the Chinese Academy of Sciences, identifies conserved and species-specific regulatory signatures for primordial germ cells and somatic cells. It provides a resource for understanding evolutionary programs in mammalian gonad development.

Use Cases

• Identify evolutionarily conserved gene expression patterns based on single-cell transcriptome data.
• Analyze species-specific signaling pathways and cell-cell interactions mentioned in the description.
• Discover potential cis-regulatory elements and key transcription factors in primordial germ cells and somatic cells.
• Perform comparative genomics analysis across goats, pigs, macaques, and humans.

Strengths

• Integrates two complementary data modalities: single-cell transcriptome and chromatin accessibility.
• Covers four distinct mammalian species (goats, pigs, macaques, humans) for comparative analysis.
• Focuses on early developmental stages of gonads, a key period for sex determination.

Limitations

• Row count and dataset size are unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Last update date is unknown; freshness unverified.

Provenance

Source

Chinese Academy of Sciences

Collection Method

Single-cell transcriptome and chromatin accessibility analysis of early gonad tissues.