Integrin α2 Modulation in Trabecular Meshwork Cells for Glaucoma Research

A 4.3 MB DOCX file authored by Xiao Ding and last updated on 2026-05-11. The document describes a study investigating the role of integrin α2 in determining the mesenchymal-to-endothelial phenotype transition of human trabecular meshwork cells, relevant to intraocular pressure regulation in glaucoma. Experiments used western blot analysis, immunohistochemistry, collagen contraction assays, and the integrin α2 inhibitor BTT3033.

Use Cases

• Train models to predict cell phenotype based on integrin α2 expression levels described in the study.
• Analyze the relationship between TGF-β2 stimulation and integrin α2 expression for glaucoma biomarker discovery.
• Study the pharmacological effects of integrin α2 inhibitors like BTT3033 on Smad2 phosphorylation pathways.

Strengths

• The dataset is licensed under CC-BY-4.0, allowing for broad reuse and sharing.
• The description provides specific experimental details, including the use of western blot analysis, immunohistochemistry, and the inhibitor BTT3033.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Experimental data from western blot analysis, immunohistochemistry, and collagen contraction assays on human trabecular meshwork cells.

Freshness

Last updated 2026-05-11 06:00:25; freshness should be verified.