Comprising behavioral data from a study comparing interval timing abilities in Nrxn1+/-, Nrxn1+/+, and Nrxn1ΔS5/- rescue mice using a 15-second target interval. The study involved two-month-old male mice trained to obtain sucrose rewards after a stimulus onset, with performance analyzed across individual trials. The analysis revealed earlier timing responses in Nrxn1+/- mice, suggesting a bias in long-term memory.
Use Cases
- Analyze timing response curves from non-reinforced probe trials to compare performance between Nrxn1+/+, Nrxn1+/-, and Nrxn1ΔS5/- mouse genotypes.
- Investigate the relationship between the 15-second target interval and the earlier termination of responding observed in Nrxn1+/- mice.
- Model the leftward shift in timing responses as a potential behavioral marker for autism spectrum disorder in genetic murine models.
Strengths
- Data is derived from a controlled experiment using a defined 15-second target interval in the peak interval procedure.
- Includes comparisons across three specific mouse genotypes: Nrxn1+/+, Nrxn1+/-, and Nrxn1ΔS5/- rescue mice.
- Focuses on two-month-old male mice, providing a consistent age and sex cohort for analysis.
Limitations
- The dataset scope is limited to male mice, excluding potential sex-specific effects on interval timing.
- Sample size and number of trials are not specified, limiting assessment of statistical power.
- Data is specific to a single genetic model (Nrxn1 mutation) and a 15-second interval, which may limit generalizability.
Provenance
- Source
- Borealis Harvested Dataverse, authored by Roddick, Kyle M.
- Collection Method
- Experimental data from the peak interval procedure, where mice were trained to obtain sucrose rewards 15 seconds after a stimulus onset and tested in non-reinforced probe trials.
- Time Range
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- Freshness
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- Geography
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