Comparative Proteogenomic Analysis of 686 Archaeal Genomes for Extremophile Adaptation

686 high-quality archaeal genomes and proteomes sourced from the PATRIC database were analyzed. The study compares genomic features, protein domain distributions, and physicochemical properties across archaeal species to investigate adaptations to extreme environments. The dataset was produced by Liang Wang of Nanjing Agricultural University.

Use Cases

• Identify protein domains associated with extremophilic lifestyles based on distribution patterns.
• Compare physicochemical properties like protein stability and hydrophobicity across different archaeal groups.
• Investigate the role of domains of unknown function (DUFs) and mini proteins in archaeal physiology.
• Analyze correlations between genomic features like G+C content and environmental adaptation.

Strengths

• Includes 686 high-quality archaeal genomes, providing a substantial sample size for comparative analysis.
• Analysis covers multiple feature types: genomic features, protein domain distributions, and protein physicochemical properties.
• Data is sourced from the authoritative Pathosystems Resource Integration Center (PATRIC) database.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Last update date is unknown; freshness unverified.

Provenance

Source

Pathosystems Resource Integration Center (PATRIC) database

Collection Method

Comparative analysis of publicly available genomic and proteomic data.