Dragon Fruit Extract Bioactivity Data for Colon Cancer Research

A research dataset investigating the antioxidant and anticancer properties of methanol extracts from white and purple dragon fruit pulp and peel against human colon cancer cells. The dataset includes results from antioxidant assays, HPLC analysis for phenolic composition, and cytotoxicity, cell migration, and apoptosis assays on HT-29 cells. It was authored by Çiğdem Gökçek-Saraç and uploaded to figshare in June 2026.

Use Cases

• Compare antioxidant capacities of fruit extracts based on reported IC50 values from DPPH assays.
• Analyze cytotoxicity against HT-29 colon cancer cells based on provided extract IC50 concentrations.
• Investigate apoptotic pathway modulation based on described changes in Bax, caspase-12, and Bcl-2 marker expression.
• Study the correlation between phenolic/flavonoid content and bioactivity as suggested by the comparative analysis of peel vs. pulp extracts.

Strengths

• Includes specific quantitative results, such as antioxidant IC50 values of 0.96 and 1.28 µg/mL for peel extracts.
• Reports detailed biological endpoints, including fold-increases in early apoptosis (e.g., 6.86-fold) and cytotoxicity IC50 values (e.g., 135.8 µg/mL).
• Released under a permissive CC-BY-4.0 license, allowing for broad reuse and sharing.

Limitations

• The dataset is very small (194.0 KB), consisting of document files (PDF, DOCX) rather than structured data tables, limiting computational analysis.
• Column-level documentation is absent; field semantics and raw data must be extracted manually from the provided documents.
• Row count is unknown, which may limit suitability assessment for statistical modeling.

Provenance

Source

figshare

Collection Method

Experimental laboratory research involving antioxidant assays, HPLC analysis, and cell culture assays.

Freshness

Last updated 2026-06-03 17:54:46; freshness should be verified.