Pharmaceutical Excipient Concentrations Measured by Ion Chromatography

A method for quantifying glycerol, sorbitol, and sucrose in pharmaceutical formulations using ion chromatography with pulsed amperometric detection. The dataset, authored by Raul Arruda Artisiani and last updated in April 2026, includes validation results demonstrating linearity from 1–100 mg L⁻¹, precision with RSD ≤ 0.7%, and low detection limits between 3.0–24 µg L⁻¹.

Use Cases

• Validate analytical methods for pharmaceutical quality control based on described linearity and precision metrics.
• Quantify undeclared excipient concentrations in commercial products based on the method's application to real samples.
• Assess the environmental impact of analytical procedures based on the AGREE greenness score of 0.67.
• Perform simultaneous analysis of multiple excipients based on the baseline separation achieved within 8 minutes.

Strengths

• Method validation followed ANVISA guideline RDC n° 166/2017.
• Demonstrated excellent linearity (r² ≈ 0.999) across 1–100 mg L⁻¹.
• Achieved good precision with relative standard deviation ≤ 0.7%.
• Reported low limits of detection, ranging from 3.0 to 24 µg L⁻¹.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (121.5 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Developed and validated ion chromatography with pulsed amperometric detection (IC–PAD) method.

Time Range

Method validation date not specified; dataset last updated April 2026.

Freshness

Last updated 2026-04-14 07:03:57; freshness should be verified.

Geography

Geographic scope of the commercial products analyzed is not specified.