Red Panda Amdoparvovirus RpAPV-Gd1: Genomic and Pathogenicity Data

A 2026 study by Liulu Yang reports the first isolation and characterization of a highly pathogenic red panda amdoparvovirus (RpAPV-Gd1) from a fatal case in China. The dataset includes phylogenetic analysis, in vitro cell tropism results, and reverse genetics findings identifying a key virulence determinant (VP2-S447R) in a BALB/c mouse model. The data is shared under a CC-BY-4.0 license.

Use Cases

• Phylogenetic analysis of amdoparvovirus strains based on whole-genome sequence data.
• Modeling viral pathogenicity and acute lung injury based on identified VP2 protein mutations.
• Studying in vitro cell tropism in human and animal cell lines mentioned in the description.
• Investigating cytokine storm mechanisms associated with fatal respiratory disease in animal models.

Strengths

• Includes specific whole-genome identity data (95.4% with RpAPV-2).
• Contains experimental results from a defined animal model (100% mortality in BALB/c mice).
• Identifies a specific molecular determinant of pathogenicity (VP2-S447R substitution).

Limitations

• Row count and column-level documentation are absent; data structure must be inferred from the provided PDF/DOCX files.
• The dataset's 5.9 MB size suggests it is a small-scale study, potentially limiting statistical power for some analyses.

Provenance

Source

figshare, author Liulu Yang.

Collection Method

Viral isolation, histopathological examination, phylogenetic analysis, and reverse genetics from a captive red panda case in China.

Time Range

Study published in 2026.

Freshness

Last updated 2026-04-14 10:10:03.

Geography

Data originates from a case in China.