KDM4B/DHX9 in SCLC Chemoresistance: RNA-seq and IHC Data from 9 Cell Lines

9.3 MB of data from a study investigating histone demethylases in small cell lung cancer chemoresistance. The dataset includes RNA sequencing results from nine chemoresistant cell lines and immunohistochemical analysis of patient tissues, published by Qiong Lyu on figshare in 2026. Files are provided in BED, XLS, and TXT formats.

Use Cases

• Identify genes associated with chemoresistance based on RNA-seq data from resistant cell lines.
• Validate KDM4B expression patterns using immunohistochemical analysis data from patient tissues.
• Investigate the MYCN-Hedgehog signaling pathway interaction described in the mechanistic study.
• Test for synergistic drug effects using data on DHX9 inhibitor combined with cisplatin and etoposide.

Strengths

• Data is derived from nine chemoresistant cell lines established via gradual dose escalation.
• Findings were validated using two neuroendocrine SCLC cell lines and their chemoresistant counterparts.
• Includes in vitro and in vivo experimental data supporting the mechanistic conclusions.

Limitations

• Row count and specific column definitions are unknown, requiring manual inspection after download.
• The dataset's 9.3 MB size suggests it is relatively small in scale.
• The association of KDM4B with neuroendocrine subtypes noted in the description requires further investigation.

Provenance

Source

figshare, author Qiong Lyu.

Collection Method

Data generated from RNA sequencing of chemoresistant cell lines, linear regression, meta-analysis, and immunohistochemical validation.

Freshness

Last updated 2026-04-29 07:02:26.