Kinetic Analysis of D-chirality Cell Penetrating Peptide Uptake and Expulsion

Manibarathi Vaithiyanathan from the Louisiana State University System investigated the cellular internalization of unstructured D-chirality cell penetrating peptides (CPPs). The work reports a three-fold increase in uptake and a 50-fold increase in stability for D-chirality peptides compared to L-chirality counterparts. Findings highlight a new exocytosis-independent expulsion pathway and the peptides' potential as bio-vectors.

Use Cases

• Modeling peptide uptake kinetics based on time, concentration, temperature, and energy-dependent studies.
• Predicting intracellular stability of D-chirality peptides based on reported 50-fold stability increase.
• Analyzing peptide export pathways based on the described exocytosis-independent expulsion mechanism.

Strengths

• Quantifies a three-fold increase in peptide uptake.
• Reports a 50-fold increase in intracellular stability for D-chirality peptides.
• Describes a novel exocytosis-independent expulsion pathway for internalized peptides.

Limitations

• Column-level documentation is absent; field semantics must be inferred from the paper.
• Row count is unknown, which may limit suitability assessment for large-scale ML.
• The dataset's freshness and last update date are unknown.

Provenance

Source

Manibarathi Vaithiyanathan, Louisiana State University System

Collection Method

Likely contains experimental results from a series of time, concentration, temperature, and energy-dependent studies.