SARS-CoV-2 Antibody Kinetics in ICU and Non-ICU COVID-19 Patients

130 blood samples from 38 COVID-19 patients were collected to investigate IgM and IgG responses against SARS-CoV-2 nucleocapsid and spike proteins. The dataset includes longitudinal samples from 11 ICU and 27 non-ICU patients, with antibody levels detected by ELISA. Analysis was conducted by researchers from the First Affiliated Hospital of Guangzhou Medical University.

Use Cases

• Modeling antibody kinetics over time based on longitudinal sampling from the same patients.
• Comparing immune response profiles between ICU and non-ICU patient groups based on N-IgG and S-IgG levels.
• Evaluating combined IgM and IgG detection for early SARS-CoV-2 infection identification as described in the study.
• Investigating correlations between S-IgG levels and clinical markers like C-reactive protein (CRP) for prognosis prediction.

Strengths

• Includes 130 blood samples from 38 patients, providing multiple data points per individual.
• Features longitudinal data with samples collected along the disease course from the same patients.
• Compares two distinct clinical cohorts: 11 ICU patients and 27 non-ICU patients.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• Last update date is unknown; freshness unverified.
• Data may reflect geographic and institutional bias inherent to a single hospital study.

Provenance

Source

First Affiliated Hospital of Guangzhou Medical University

Collection Method

Serum antibody levels (IgM, IgG) against SARS-CoV-2 N and S proteins were detected by ELISA from patient blood samples.