KissBimbova_data: Molecular Changes After Spinal Cord Injury in Rats

KissBimbova_data contains molecular data from a study investigating glial cell responses after traumatic spinal cord injury in a rat model. The dataset compares the effects of three anti-inflammatory drugs—siponimod, atorvastatin, and methylprednisolone—on microglial activation, astrocytic reactivity, and markers of axonal and myelin integrity. Quantitative RT-PCR data was collected from cranial, lesion, and caudal spinal cord segments at 2 and 6 weeks post-injury.

Use Cases

• Compare the molecular effects of siponimod, atorvastatin, and methylprednisolone based on the drug treatment groups described.
• Analyze time-dependent changes in glial cell activation based on data from 2 and 6 weeks post-injury.
• Investigate region-specific molecular profiles based on data from cranial, lesion, and caudal spinal cord segments.
• Study correlations between anti-inflammatory treatment and markers of axonal and myelin integrity mentioned in the description.

Strengths

• Data is derived from a controlled experimental model (rat Th9 compression injury).
• Includes temporal analysis with data points at 2 and 6 weeks post-injury.
• Compares three clinically relevant anti-inflammatory drug treatments.
• Dataset is openly available under a CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 52.7 KB, indicating limited scope.

Provenance

Source

Katarina Kiss Bimbova via figshare

Collection Method

Data generated via quantitative RT-PCR analysis of spinal cord tissue from a rat model.

Time Range

Data collected at 2 and 6 weeks post-injury.

Freshness

Last updated 2026-05-13 07:05:11; freshness should be verified.