29 Labdane Diterpenoids from Andrographis paniculata with Anti-Viral Activity

A phytochemical analysis of Andrographis paniculata identified 29 labdane diterpenoids, including eight previously unreported compounds. The dataset, authored by Jiang-Hu Wang and last updated in June 2026, includes structural data from NMR, HRESIMS, and X-ray crystallography. It reports anti-Tomato Spotted Wilt Virus (TSWV) activity, with one compound showing stronger protective activity than the positive control.

Use Cases

• Identify potential lead compounds for pesticide development based on reported anti-TSWV activity.
• Analyze structure-activity relationships among diterpenoids based on the described 6/6/5 and 6/6/6/5 scaffolds.
• Validate computational chemistry models using the quantum chemical calculation and X-ray crystallographic data mentioned.
• Study plant defense pathway activation based on the described salicylic acid and photosynthetic pathway mechanisms.

Strengths

• Includes 29 distinct compounds with eight being newly reported.
• Compound structures were determined using multiple analytical techniques including NMR and X-ray crystallography.
• Reports specific biological activity (EC50 values) against Tomato Spotted Wilt Virus.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 649.0 B, indicating limited scope.

Provenance

Source

figshare

Collection Method

Phytochemical analysis and biological assays performed as part of research into TSWV inhibitors.

Freshness

Last updated 2026-06-03 20:04:12; freshness should be verified.