29 Labdane Diterpenoids from Andrographis Paniculata with Anti-TSWV Activity

A phytochemical study of Andrographis paniculata identified 29 labdane diterpenoids, including eight novel compounds. The dataset includes structural characterization data from NMR, HRESIMS, IR, UV, and X-ray crystallography. Anti-TSWV bioassays identified compound 9 with an EC50 of 100.7 μg/mL, stronger than the positive control.

Use Cases

• Structure-activity relationship modeling based on the 29 diterpenoid structures and their bioassay results.
• Virtual screening for novel antiviral compounds based on the uncommon 6/6/5 and 6/6/6/5 scaffolds described.
• Comparative analysis of compound efficacy against Tomato spotted wilt virus using the provided EC50 values.
• Investigation of plant defense pathway activation (photosynthetic and salicylic acid) based on the mechanistic RNA-sequencing analysis mentioned.

Strengths

• Includes 29 characterized compounds, with 8 being previously unreported.
• Structural elucidation employed multiple analytical techniques, including X-ray crystallographic analysis.
• Bioassay data includes a specific EC50 value (100.7 μg/mL) for the most active compound.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect bias inherent to a single plant species study.

Provenance

Source

figshare

Collection Method

Phytochemical analysis and bioassay of Andrographis paniculata plant material.

Freshness

Last updated 2026-06-03 20:04:10; freshness should be verified.