LC3-Linked Golgi-Bypass Exocytosis Data for Epithelial Barrier Defense

Jiabin Wang's research data from 2026 defines LACES, a conserved cellular pathway that accelerates membrane protein delivery in response to microbial cues. The dataset includes video and document files illustrating the pathway's function in Caenorhabditis elegans and mammalian epithelia. It demonstrates how phenazine-1-carboxamide triggers a VPS-34-dependent route to improve host survival during infection.

Use Cases

• Modeling LC3/Atg8-associated carrier exocytosis (LACES) based on the described pathway mechanism
• Analyzing the impact of microbial cues on membrane trafficking based on the phenazine-1-carboxamide (PCN) trigger
• Studying Golgi-bypass routes for ABC transporter delivery based on the PGP-1 example
• Comparing infection response pathways between C. elegans and mammalian epithelia based on the cross-species findings

Strengths

• Includes video (MP4) and document (DOCX) files providing multimodal evidence for the biological pathway
• Data is licensed under CC-BY-4.0, permitting open sharing and adaptation
• Describes a conserved pathway validated in both C. elegans and mammalian cell models

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Description metadata is limited; actual data quality requires manual inspection after download

Provenance

Source

figshare

Collection Method

Experimental research data from the study 'LC3-linked Golgi-bypass exocytosis fortifies epithelial barrier defense'

Time Range

Publication date 2026

Freshness

Last updated 2026-04-13 06:20:04; freshness should be verified

Geography

Laboratory research, likely international collaboration