Bi-Triazine Cross-Linker Effects on Cyclic and Dimeric Peptide Conformation and Activity

Eight bi-triazine cross-linkers with varied bond length, angle, aromaticity, and symmetry were used to modulate peptide conformation and biological activity. The dataset likely contains results from binding assays, cell studies, and in vivo PET/CT imaging for cyclic RGD and dimeric KTLLPTP peptide models. It was authored by Quan Zuo and uploaded to figshare on 2026-04-15.

Use Cases

• Modeling the relationship between cross-linker geometry and peptide conformation based on described bond length, angle, and symmetry.
• Predicting peptide-protein affinity and tumor uptake based on cross-linker aromaticity and symmetry features.
• Optimizing bivalent binding in dimeric peptide systems using the described 'molecular ruler' effect.
• Identifying lead therapeutic candidates by analyzing integrated assay and imaging data.

Strengths

• Systematically evaluates eight distinct bi-triazine cross-linkers.
• Integrates data from binding assays, cell studies, and in vivo PET/CT imaging.
• Identifies a specific lead candidate ([68Ga]Ga-8a) with reported tumor contrast (~5 %ID/mL).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Dataset is very small (16.6 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Experimental platform integrating binding assays, cell studies, and in vivo imaging.

Time Range

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Freshness

Last updated 2026-04-15 11:37:29; freshness should be verified.

Geography

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