LGALS3 in Liver Cirrhosis: Bulk and Single-Cell RNA Sequencing Data

4.5 GB of bulk and single-cell RNA sequencing data from healthy and cirrhotic human and mouse liver samples. The dataset, authored by Fengchun Li and released under CC-BY-4.0, focuses on the role of Galectin-3 (LGALS3) in macrophage function and hepatic stellate cell activation. It was last updated on May 7, 2026.

Use Cases

• Identify hub genes related to efferocytosis in liver cirrhosis based on bulk RNA-seq data.
• Analyze LGALS3 expression profiles across macrophage subpopulations using single-cell RNA-seq data.
• Investigate ligand-receptor interactions and molecular structures involved in hepatic stellate cell activation.
• Validate computational predictions of disease mechanisms with multi-level experimental data.

Strengths

• Integrates bulk and single-cell RNA sequencing data from both human and mouse liver tissues.
• Includes multi-level experimental validation for mechanistic studies.
• Released under a permissive CC-BY-4.0 license for open reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Bulk and single-cell RNA sequencing combined with experimental validation.

Freshness

Last updated 2026-05-07 08:22:11.