QueC Protein Superfamily Supplemental Data: Sequence Networks and Structures

Libby et al's supplemental data provides supporting figures, tables, and files for a study on the functional diversification of the QueC protein superfamily (PF06508). The 304.3 MB collection includes CSV files of proteins analyzed in Sequence Similarity Networks and genomic neighborhoods, a ChimeraX file of protein structures, and PDFs. Author Geoffrey Hutinet deposited the data on figshare in April 2026.

Use Cases

• Analyze protein clusters in Supplemental Data 1 to map functional diversification of the PF06508 superfamily using Sequence Similarity Networks.
• Investigate genomic context in Supplemental Data 2 to infer gene function and operon associations for QueC-like proteins.
• Visualize and compare protein structures in the Supplemental Data 3 ChimeraX file to study active site remodeling in QatC and Cap9 systems.
• Validate the refined catalytic signature for tRNA modification by cross-referencing sequence data with experimental results from the main publication.
• Study the expansion of the QueC scaffold into cofactor biosynthesis and purine salvage pathways using the provided supplemental tables and figures.

Strengths

• Data is directly linked to a peer-reviewed publication, providing experimental validation for the computational analyses.
• Includes multiple data modalities: tabular protein lists (CSV), structural models (CXS), and explanatory figures (PDF).
• Released under a permissive CC-BY-4.0 license, enabling reuse with attribution.

Limitations

• The dataset is supplemental; core analysis requires the main publication for full context and interpretation.
• Sample size and specific row counts for the protein lists in CSV files are not provided in the metadata.
• Data is static and represents a snapshot of the superfamily analysis at the time of publication.

Provenance

Source

figshare deposit by author Geoffrey Hutinet, associated with a research publication.

Collection Method

Generated through Sequence Similarity Network analysis, genomic neighborhood analysis, and structural modeling as described in the linked study.

Time Range

null

Freshness

Last updated in April 2026, indicating recent deposition aligned with publication.

Geography

null