Licochalcone A Effects on Cisplatin-Induced Kidney Injury

Experimental data investigates Licochalcone A's mitigation of cisplatin-induced nephrotoxicity. The dataset includes results from in vivo murine models and in vitro HK-2 cell assays, measuring renal function, oxidative stress, ferroptosis markers, and mitochondrial health. It was authored by Feihu Zhang and uploaded to figshare in April 2026.

Use Cases

• Predict renal injury severity from ferroptosis markers like Fe2+ accumulation and lipid peroxidation levels.
• Model the relationship between Nrf2/GPX4 pathway activation and metrics of mitochondrial dysfunction.
• Analyze metabolomic profiles to identify shifts in energy metabolism and glutathione homeostasis post-treatment.
• Correlate histopathological scores from HE/Masson staining with biochemical measurements of renal function.

Strengths

• Dataset includes results from both in vivo and in vitro experimental models.
• Measures multiple biological endpoints: histology, renal function, oxidative stress, and metabolomics.
• License is permissive CC-BY-4.0 for reuse.

Limitations

• Small dataset at 4.6 MB, suggesting limited sample size or feature count.
• Specific row count and column names are unknown, complicating direct analysis.
• Data is static from a single study, limiting generalizability.

Provenance

Source

figshare, authored by Feihu Zhang.

Collection Method

Generated from laboratory experiments including murine models, cell culture, molecular docking, and metabolomic analysis.

Freshness

Data uploaded in April 2026.