Human Heart Transcriptome Atlas Across Lifespan from Single-Nucleus RNA Sequencing

A single-nucleus RNA sequencing atlas contains data from 442,239 nuclei isolated from 54 non-failing myocardial tissues of 29 individuals. The dataset spans human development, adulthood, and aging, covering left and right ventricles. Hao Jia published this resource on figshare in April 2026.

Use Cases

• Identify cell type-specific transcriptional trajectories across the lifespan using gene expression profiles.
• Analyze age-associated transcriptional states in cardiomyocytes for senescence- and disease-related signatures.
• Build cardiac transcriptomic age prediction models leveraging lifespan-resolved single-nucleus data.
• Investigate regulatory network activity, such as PRDM16, and its decline with age in cardiomyocytes.
• Compare transcriptional programs between non-failing hearts and cardiomyopathies for accelerated aging signatures.

Strengths

• Data from 442,239 nuclei provides high cellular resolution.
• Covers 54 tissue samples from 29 individuals across the human lifespan.
• Includes both left and right ventricle samples for comparative analysis.

Limitations

• Sample size of 29 individuals is modest for population-level inferences.
• Limited to non-failing myocardial tissues, excluding many cardiac disease states.
• The 9.3 MB file size suggests aggregated or processed data, not raw sequencing reads.

Provenance

Source

figshare, authored by Hao Jia.

Collection Method

Single-nucleus RNA sequencing of human myocardial tissues.

Time Range

Covers human developmental stages, adulthood, and aging.

Freshness

Last updated April 2026.

Geography

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