Human Heart Single-Nucleus RNA-Seq Atlas Across the Lifespan

A single-nucleus RNA sequencing atlas of 442,239 nuclei from 54 non-failing myocardial tissues of 29 individuals. The data spans development, adulthood, and aging, covering left and right ventricles. It was authored by Hao Jia and last updated on 2026-04 05.

Use Cases

• Modeling transcriptional trajectories of cardiac aging based on lifespan-resolved single-nucleus data.
• Identifying age-associated cell states and regulatory networks, such as PRDM16 activity in cardiomyocytes.
• Training transcriptomic age prediction models for non-failing and diseased hearts.
• Investigating cell type-specific stress responses and inflammatory signaling across the lifespan.

Strengths

• Contains 442,239 single-nucleus transcriptomes from 54 human heart tissues.
• Covers a lifespan range from development through aging across 29 individuals.
• Includes data from both left and right ventricles for comparative analysis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect bias inherent to the specific 29 individuals and 54 tissues sampled.

Provenance

Source

figshare, authored by Hao Jia.

Collection Method

Single-nucleus RNA sequencing of non-failing human myocardial tissues.

Time Range

Samples span development, adulthood, and aging (specific years not provided).

Freshness

Last updated 2026-04-05 05:45:01; freshness should be verified.

Geography

Human heart tissues; specific geographic origin is unknown.