Dlx4os: LncRNA Regulation of Melanoma Phenotype Switching

Murine melanoma cell line data identifies long non-coding RNAs involved in cellular plasticity. The dataset focuses on the lncRNA Dlx4os, demonstrating its role in promoting a mesenchymal-like state and regulating markers like Sox10 and Mitf. Findings suggest Dlx4os as a potential biomarker and therapeutic target for influencing treatment response and metastasis.

Use Cases

• Identifying lncRNA candidates involved in melanoma phenotype switching based on expression profiles.
• Investigating cis-regulatory relationships between lncRNAs and neighbouring protein-coding genes.
• Validating phenotypic state markers (e.g., Sox10, Mitf, Tgfβ) following genetic perturbation.
• Assessing the role of specific lncRNAs (e.g., Dlx4os) in invasive and migratory potential.
• Exploring orthologous lncRNA functions between murine models and human melanoma.

Strengths

• Data is openly licensed under CC-BY-4.0, facilitating reuse and redistribution.
• Cross-platform presence on figshare indicates established sharing and potential for visibility.
• Research context is specific, focusing on a defined lncRNA (Dlx4os) and its mechanistic role.

Limitations

• Column names and row counts are not provided, limiting understanding of the data's structure and scale.
• The dataset size (5117065) is given without units, making its practical scope unclear.
• Metadata is incomplete, lacking information on the originating organization and specific data collection methods.

Provenance

Source

Ana Luisa Pedroso Ayub

Collection Method

Analysis of lncRNAs across different murine melanoma cell lines, likely involving genetic knockdown and expression profiling.

Time Range

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Freshness

Last updated on 2026-03-19.

Geography

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