MIR4435-2HG: Molecular Data on Succinylation and EMT in Head and Neck Cancer

Research data from a 2026 study investigating the role of long noncoding RNA MIR4435-2HG in head and neck squamous cell carcinoma (HNSCC). The dataset, authored by Shujin He and shared under a CC-BY-4.0 license, includes TIF and DOCX files totaling 5.4 MB. It supports findings on a signaling loop involving USF1, AKT, and CREB1 that drives tumor cell migration and invasion.

Use Cases

• Validate bioinformatic screening results for downstream effectors of lncRNAs based on the described integrated analyses.
• Study the relationship between transcription factor succinylation and protein stability based on the mechanistic findings for USF1.
• Investigate positive feedback regulatory circuits in cancer signaling based on the described MIR4435-2HG–USF1–AKT–CREB1 loop.
• Correlate molecular marker expression with clinical pathological stages based on the association of MIR4435-2HG with T stage, clinical stage, and grade.

Strengths

• Includes primary research files in TIF and DOCX formats, totaling 5.4 MB.
• Mechanistic findings are validated through dual-luciferase reporter assays and RT-qPCR analyses as described.
• Released under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• Row count and column-level documentation are unknown, limiting suitability assessment.
• The dataset's 5.4 MB size suggests it is relatively small and may contain limited raw data.
• Description metadata is limited; actual data structure and content require manual inspection after download.

Provenance

Source

figshare

Collection Method

Generated from integrated analyses across multiple public databases and functional validation experiments as described.

Time Range

Study published in 2026.

Freshness

Last updated 2026-05-14 09:48:04.

Geography

null