LNP-Delivered CAR-mRNA Images for Choroidal Melanoma Therapy Study

Images from a 2026 study by Wenfei Chen demonstrating macrophage-targeted therapy for choroidal melanoma. The dataset includes immunofluorescence, flow cytometry, and bioluminescence imaging results from a murine model, showing reduced tumor burden and extended survival. The data is 7.9 MB in size and licensed under CC-BY-4.0.

Use Cases

• Validate macrophage reprogramming techniques based on immunofluorescence images of M1/M2 phenotypes.
• Assess tumor progression based on bioluminescence imaging data.
• Evaluate safety of lipid nanoparticle delivery based on histological analysis images.
• Compare CAR expression levels based on flow cytometry data.
• Model in vivo CAR-macrophage production based on the described experimental results.

Strengths

• Includes 7.9 MB of experimental images (TIF, JPEG) supporting the findings.
• Results demonstrate a significant reduction in tumor burden and extended survival in the murine model.
• No systemic toxicity was observed, as confirmed by hematological, biochemical, and histological analyses.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (7.9 MB), which may limit the scope of analysis.

Provenance

Source

figshare

Collection Method

Experimental data generated from a murine choroidal melanoma model.

Freshness

Last updated 2026-04-10 10:38:23; freshness should be verified.