Systematic Review of Local Otoprotective Agents for Cisplatin-Induced Hearing Loss

Amirhossein Masroor authored a systematic review investigating non-sodium thiosulfate otoprotective agents for preventing cisplatin-induced hearing loss. The review, last updated in 2026, analyzed 70 preclinical and eight clinical studies, categorizing agents by biological mechanism. It concluded that no locally applied alternative agent currently matches systemic sodium thiosulfate for safety and efficacy in pediatric patients.

Use Cases

• Identify candidate otoprotective agents for preclinical research based on the review's categorization of 45 different agents.
• Evaluate the efficacy of dexamethasone and N-acetylcysteine in clinical settings based on the analysis of multiple randomized and non-randomized trials.
• Compare drug delivery methods and administration routes for local otoprotection based on the summary provided in the review.
• Design future clinical studies on otoprotection by identifying gaps in optimal dosage, delivery method, and timing highlighted in the review.

Strengths

• The review provides a structured analysis of 78 total studies (70 preclinical, 8 clinical).
• Agents are categorized by biological mechanism (e.g., anti-inflammatory, chemical deactivators), offering a clear analytical framework.
• Specific clinical trial results for dexamethasone and N-acetylcysteine are reported, including statistical significance findings.

Limitations

• The dataset is a 791.2 KB DOCX document, which is a small, text-only systematic review rather than a primary data collection.
• The review's conclusion states it did not identify any local alternative agents that could reliably replace systemic sodium thiosulfate for pediatric use.
• Row count and column-level documentation are absent, limiting suitability for direct computational analysis.

Provenance

Source

figshare

Collection Method

Systematic review of published preclinical and clinical studies.

Freshness

Last updated 2026-05-02 05:20:03