HIV-1 Plasma Cytokine and Virome Profiles During Long-Term Antiretroviral Therapy

Cytokine and plasma virome data from people living with HIV on antiretroviral therapy for 5–20 years. The dataset includes measurements for cytokines IL-10, VEGF, GM-CSF, PDGF-BB, FGF basic, IL-1rα, IL-12, and IL-4, alongside virome data for anellovirus and human pegivirus 1. It was authored by Yingying Ma and last updated on 2026-05-24.

Use Cases

• Modeling the relationship between specific anellovirus species and elevated cytokines like IL-10, GM-CSF, and VEGF.
• Developing biomarkers to discriminate immune non-responders from immune responders based on cytokine and virome combinations.
• Investigating the long-term impact of antiretroviral therapy on plasma virome composition and cytokine network homeostasis.

Strengths

• Includes specific fold-change values for cytokine levels (5.3- to 27.9-fold elevated, 1.4- to 2.6-fold decreased).
• Defines a clear patient cohort: people on antiretroviral therapy for 5–20 years.
• Data is available under a permissive CC-BY-4.0 license.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small at 36.6 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Data likely gathered via metagenomic sequencing and multiplex immunoassays from a clinical cohort.

Time Range

Covers patients on therapy for 5–20 years.

Freshness

Last updated 2026-05-24 03:12:51; freshness should be verified.