Nogo-A and mGlu3 Mouse Hippocampal Data from Schizophrenia Study

Experimental data from a study investigating the role of the Nogo-A protein in mouse CA3 hippocampal circuitry and its link to schizophrenia. The research, conducted by Stewart Berry at the University of Zurich, involved patch clamp recordings, analysis of mGlu3 receptor expression, theta oscillation measurements, and behavioral tests using modified Morris water maze tasks. The dataset likely contains measurements from these experiments, linking Nogo-A loss to network hyperactivity, mGlu3 downregulation, and altered spatial navigation strategies.

Use Cases

• Modeling hippocampal network hyperactivity based on electrophysiological recordings from Nogo-A knockout mice.
• Analyzing correlations between gene/protein expression (Rtn4/Nogo-A, mGlu3) and electrophysiological or behavioral phenotypes.
• Investigating the relationship between theta oscillation patterns and spatial navigation strategies in genetically modified mouse models.

Strengths

• Data is derived from controlled experimental methods including patch clamp recordings and behavioral assays.
• Study design includes specific genetic manipulations (Nogo-A-/-) and comparisons to established models (mGlu3-/-).
• Research links molecular, circuit, and behavioral levels of analysis within a defined brain region (CA3 hippocampus).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Last update date is unknown; freshness unverified.

Provenance

Source

University of Zurich

Collection Method

Experimental data from mouse model studies, including electrophysiology, molecular biology, and behavioral testing.